4.5 Letter

Could intradermal be an economical alternative route of administration for Japanese encephalitis vaccines?

Journal

JOURNAL OF TRAVEL MEDICINE
Volume 28, Issue 1, Pages -

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/jtm/taaa181

Keywords

Japanese encephalitis; intradermal; meta-analysis; vaccine

Funding

  1. Australian National Health and Medical Research Council [APP1158469]

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Research has shown that administering smaller doses of JE vaccine intradermally is as effective as standard doses given subcutaneously, potentially increasing vaccination uptake due to the cheaper and still effective method of administration.
Highlight Uptake of Japanese encephalitis (JE) vaccine remains low among travellers, with cost of vaccines likely being one of the main hurdles. We found that smaller doses of JE vaccine administered via intradermal (ID) had similar effect on seroconversion than standard doses administered via subcutaneous. ID is a cheaper yet effective route of JE vaccine administration, and could potentially increase vaccination uptake among travellers.

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