Journal
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
Volume 17, Issue 12, Pages 3205-3216Publisher
SPRINGER
DOI: 10.1007/s13738-020-02061-3
Keywords
Doxorubicin; Nanogel; Magnetic nanoparticle; Solid-phase extraction; Central composite design
Categories
Funding
- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [9555]
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In this study, a new magnetic nanogel was synthesized for the extraction/pre-concentration of doxorubicin (DOX) from biological samples. The synthesized nano-sorbent was used for the pre-concentration and extraction of DOX prior to spectrophotometry determination. The influence of the main variables, including pH, sorption time, adsorbent amount, and NaCl content, was investigated and optimized by central composite design (CCD) as a response surface methodology. The optimum values obtained for each investigated variable to reach the maximum recovery are pH 5.0, sorption time = 22 min, sorbent amount = 15 mg, and NaCl content = 0%. Under these conditions, the proposed procedure represented good linearity over the range of 0.5-15 mu g mL(-1)(R-2 = 0.9991) for water samples, 2-30 mu g mL(-1)(R-2 = 0.9977) for urine samples, and 0.6-15 mu g mL(-1)(R-2 = 0.9987) for plasma samples. A comparison of the analytical merits of our method with some other published spectroscopic methods for the determination of DOX shows that the developed method is good and comparable with that of other reported methods. The accuracy of the method is confirmed by comparing the results with those obtained by analyzing the samples using a standard method.
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