Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 163, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.supflu.2020.104875
Keywords
Solubility; SC-CO2; Tamsulosin (TML); SAFT-VR EoS; Self-consistency; Levenberg-Marquardt method
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Funding
- University of Kashan, Iran [Pajoohaneh-1398/19]
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Among available methods, supercritical fluid (SCF) technology is a new and suitable approach for producing nano-sized particles. For this purpose, determination of a solid solute solubility such as pharmaceutical materials is an essential step. The present research is the first to measure Tamsulosin (TML) solubility in supercritical carbon dioxide (SC-CO2) under operating conditions of 308 to 338 K and 12 to 27 MPa. The mole fraction of TML ranged from 0.18 x 10(-6) to 1.013 x 10(-5) . Experimental data have been modeled with two main models groups; the first group consisted of semi-empirical and empirical models (e.g., Chrastil; Sodeifian et al.; Kumar & Johnston (K-J); Mendez-Santiago & Teja (MST); Bian et al.; Bartle et al.) and the second group have been SAFT-VR (statistical associating fluid theory of variable range) and Peng-Robinson (PR) equations of state. Furthermore, self-consistency test of the experimental data was performed on the solubility data. Finally, the approximate values Delta H-total, Delta H-vap and Delta H-sol enthalpies have been computed. (C) 2020 Elsevier B.V. All rights reserved.
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