4.2 Article

Cisplatin-loaded albumin nanoparticle and study their internalization effect by using β-cyclodextrin

Journal

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
Volume 41, Issue 4, Pages 393-400

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/10799893.2020.1817077

Keywords

Albumin; nanoparticles; drug delivery; cisplatin; MCF-7 cells

Funding

  1. Indian Council of Medical Research (ICMR), New Delhi (India) [RT-45/26/2018-Nan/BMS]

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The study aimed at enhancing the therapeutic and anti-cancer properties of cisplatin-loaded bovine serum albumin nanoparticles. The physicochemical characterization of the nanoparticles showed specific targeting and enhanced cytotoxicity on MCF-7 cell lines, making them a potential better option for intracellular delivery of anticancer drugs.
The present study with aim at enhancing the therapeutic and anti-cancer properties of cisplatin (CPT)-loaded bovine serum albumin (BSA) nanoparticles. The BSA nanoparticles containing CPT (CPT-BSANPs) were successfully prepared by the desolvation technique. The physicochemical characterization of the CPT-BSANPs were used by Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The particle size of CPT-BSANPs was found less than 200 nm with 75.02 +/- 0.15% entrapment efficiency (EE), while zeta potential and PDI were -17.6 mV and 0.2, respectively.In vitrorelease behavior of the CPT from the carrier suggests that about 64% of the drug gets released after 48 hrs. The anti-cancer activities of the CPT-BSANPs were tested on MCF-7 cell lines. Our studies show that CPT-BSANPs nanoparticles showed specific targeting and enhanced cytotoxicity to MCF-7 cells when compared to the bare CPT. Thus results suggest that CPT-BSANPs fallowed caveolae-mediated endocytosis, it may become better option for intracellular delivery of anticancer drug.

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