Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 76, Issue 4, Pages 513-524Publisher
SPRINGER
DOI: 10.1007/s13105-020-00767-9
Keywords
Circadian rhythm; Vascular calcification; Inflammation; Oxidative stress; Hormones; Autophagy
Categories
Funding
- National Natural Science Foundation of China [81870506, 81670676, 81422011]
- Project of Traditional Chinese Medicine in Guangdong Province [20201062]
- Basic Research Project of Shenzhen Science and Technology Innovation Committee [JCYJ20180306174648342, JCYJ20190808102005602]
- Shenzhen Futian District Public Health Research Project [FTWS2019003]
- Shenzhen Key Medical Discipline Construction Fund [SZXK002]
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Over the past decades, circadian rhythm has drawn a great attention in cardiovascular diseases. The expressions of rhythm genes fluctuate in accordance with the diurnal changes of vascular physiology, which highlights the pivotal effect of vascular clock. Recent researches show that the circadian clock can directly regulate the synthetic and secretory function of endothelial cells and phenotypic switch of vascular smooth muscle cells to adjust vascular relaxation and contraction. Importantly, dysfunction of vascular cells is involved in vascular calcification. Secretion of osteogenic cytokines and calcified vesicles in the vessel, osteogenic phenotype switch of vascular smooth muscle cells are all implicated in the calcification process. Moreover, circadian rhythm disorder can lead to abnormal hormone secretion, oxidative stress, inflammatory reaction, and autophagy, all of which should not be ignored in vascular calcification. Vascular senescence is another pathogenetic mechanism in vascular calcification. Accelerated vascular senescence may act as an important intermediate factor to promote vascular calcification in circadian rhythm disorders. In this review, we elaborate the potential effect of circadian rhythm disorder in vascular calcification and try to provide a new direction in the prevention of vascular calcification.
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