Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 11, Issue 19, Pages 8358-8364Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.0c02624
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Funding
- BioNano Health-Guard Research Center - Ministry of Science and ICT (MSIT) of Korea as Global Frontier Project [H-GUARD_2013-M3A6B2078947]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF-2017R1A5A1015365]
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We developed a synthetic strategy to form cyclodextrin-based intrananogap particles (CIPs) with a well-defined similar to 1 nm interior gap in a high yield (similar to 97%), and were able to incorporate 10 different Raman dyes inside the gap using the cyclodextrin-based host-guest chemistry, leading to strong, reproducible, and highly multiplexable surface-enhanced Raman scattering (SERS) signals. The average SERS enhancement factor (EF) for CIPs was 3.0 x 10(9) with a very narrow distribution of the EFs that range from 9.5 x 10(8) to 9.5 x 10(9) for similar to 95% of the measured particles. Remarkably, 10 different Raman dyes can be loaded within the nanogap of CIPs, and 6 different Raman dye-loaded CIPs with little spectral overlaps were distinctly detected for cancer cell imaging applications with a single excitation source. Our synthetic strategy provides new platforms in precisely forming plasmonic nanogap structures with all key features for widespread use of SERS including strong signal intensity, reliability in quantification of signal and multiplexing capability.
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