Journal
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume 72, Issue 12, Pages 1933-1945Publisher
OXFORD UNIV PRESS
DOI: 10.1111/jphp.13357
Keywords
anti-inflammatory; bioactives herbal cream; INFLATIV; Pereskia aculeata; psoriasis
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Funding
- Foundation for Research of the State of Minas Gerais (FAPEMIG) [APQ 00487-16]
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- National Council for Scientific and Technological Development (CNPq)
- Federal University of Juiz de Fora (UFJF)
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Objectives A previous study reported that the hexane fraction (HF) obtained fromPereskia aculeataleaves showed promising topical anti-inflammatory activity. Intending its future use in clinical practice, a herbal medicine cream named INFLATIV was developed. Its anti-inflammatory and antipsoriatic potential were investigated. INFLATIV was subjected to preliminary accelerated stability tests and to a degradation profile assessment. Methods INFLATIV was prepared at 6% and 12%. The anti-inflammatory activity was assessed by croton oil single and multiple application challenge in mice. Mouse tail test was used for antipsoriatic potential investigation. Cutaneous atrophy test was performed. Preliminary accelerated stability tests were performed together with a degradation profile by GC-MS analysis. Key findings The anti-inflammatory activity shown by INFLATIV was comparable to dexamethasone. However, the skin atrophy caused by that drug was not observed. INFLATIV modified skin parakeratotic differentiation into orthokeratosis, which revealed its antipsoriatic potential. The ingredients used were suitable to carry the bioactives as they were well permeated by the skin. The preliminary accelerated stability tests indicated that INFLATIV 6% is more stable than 12%. Conclusions The results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies.
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