Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 21, Pages 13920-13928Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01974
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21971262, 81973176]
- Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery [2019B030301005]
- National Mega-project for Innovative Drugs [2019ZX09721001-006-001]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2016ZT06Y337]
Ask authors/readers for more resources
A blue light-promoted formal [4+1]-annulation of diazoacetates with o-aminoacetophenones has been reported, which provides an environmentally friendly method for the synthesis of polysubstituted indoline derivatives in moderate to good yields with excellent diastereoselectivities. Detailed mechanistic studies through density functional theory calculations reveal that the (E)-enol species is the key intermediate in this transformation, and the excellent diastereoselectivity is enabled via H-bonding in the intramolecular Aldol-type addition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available