4.7 Article

Copper(II)-Catalyzed Direct Amination of 1-Naphthylamines at the C8 Site

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 19, Pages 12777-12784

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01672

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Funding

  1. National Natural Science Foundation of China [21172200, 21102134]

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A new and simple protocol for C8-H amination of 1-naphthylamine derivatives was developed using copper salt and di-tert-butyl peroxide (DTBP) as the catalyst and oxidant, respectively. This reaction proceeded smoothly under the

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