Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 21, Pages 14174-14189Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c01699
Keywords
-
Categories
Funding
- Swedish Research Council [2017-02339, 2017-00695, 2018-04589]
- Knut and Alice Wallenberg foundation [KAW 2013.0031]
- Goran Gustafsson foundation
- Kempe Foundation [SMK-1755]
- Swedish Foundation for Strategic Research [SB12-0070]
- National Institutes of Health [R01AI134847-01A1]
- Erling Perssons Stiftelse
- Michael J Fox foundation
- Swedish Research Council [2017-02339, 2018-04589, 2017-00695] Funding Source: Swedish Research Council
- Swedish Foundation for Strategic Research (SSF) [SB12-0070] Funding Source: Swedish Foundation for Strategic Research (SSF)
Ask authors/readers for more resources
A BF3 center dot OEt2 catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycles with diverse substitution. The synthesized compounds were screened for their ability to bind alpha-synuclein and amyloid beta fibrils in vitro. Analogues substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available