Journal
JOURNAL OF NEUROCHEMISTRY
Volume 157, Issue 6, Pages 2187-2194Publisher
WILEY
DOI: 10.1111/jnc.15183
Keywords
Alzheimer's disease; biomarker; isoprostane; oxidative stress; plasma
Categories
Funding
- Instituto de Salud Carlos III (Miguel Servet I Project) (Spanish Ministry of Economy and Competitiveness) [CP16/00082]
Ask authors/readers for more resources
The study analyzed the utility of lipid peroxidation biomarkers in evaluating Alzheimer's Disease progression, with some analytes showing an increasing trend over time. A regression model developed based on baseline values could predict long-term cognitive status.
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide. So, there is a need to identify AD early diagnosis and monitoring biomarkers in blood samples. The aim of this study was to analyse the utility of lipid peroxidation biomarkers in AD progression evaluation. Participants (n = 19) were diagnosed with AD at early stages (Time 0, T0), and they were re-evaluated 2 years later (Time 1, T1). Plasma biomarkers from AD patients were determined at both times. Some analytes, such as dihomo-isoprostanes (17-epi-17-F2t-dihomo-IsoP, 17-F2t-dihomo-IsoP, Ent-7(RS)-7-F2t-dihomo-IsoP), and neuroprostanes (10-epi-10-F4t-NeuroP) showed very high probability of showing an increasing trend over time. Baseline values allowed to develop an affordable preliminary regression model to predict long-term cognitive status. So, some lipid peroxidation biomarkers would deserve consideration as useful progression AD biomarkers. The developed prediction model would constitute an important minimally invasive approach in AD personalized prognosis and perhaps could have some interest also in experimental treatments evaluation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available