Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 11, Pages 3270-3277Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00540
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Funding
- Japan Society for the Promotion of Science KAKENHI [17K08348, 26460133]
- AMED [18950036]
- NIAID [64061]
- NIH [AI33066-27]
- Grants-in-Aid for Scientific Research [26460133, 17K08348] Funding Source: KAKEN
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Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.
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