Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 20, Issue 9, Pages 5349-5355Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2020.17672
Keywords
3D Scaffold; Micro/Nano Surface; Functionalized Surface; Osteoblast Behavior
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1D1A1A02017564, CRI 17010-1]
- Chonnam National University Hospital Biomedical Research Institute, Republic of Korea
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Physio-chemical surface properties to biomaterial has been attention in tissue engineering due to their properties on cell adhesion, proliferation, and differentiation. The object of this study is to evaluate the preosteoblast biological response on physio-chemical surface-layered 3D PCL scaffold and 3D PCL/beta-TCP scaffold. 3D scaffolds were fabricated by FDM 3D printing. Physio-chemical surface of 3D scaffolds were prepared by oxygen plasma and amine plasma-polymerization, respectively. The results of this study demonstrated that amine plasma-treated 3D scaffold on adhesion, proliferation, and osteogenic differentiation of the MC3T3-E1 was significantly increased compared to the other scaffolds.
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