Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 93, Issue 3, Pages 1786-1791Publisher
WILEY
DOI: 10.1002/jmv.26524
Keywords
pangolin; phylogeny; recombination; SARS-CoV-2-related virus
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Funding
- Jiangsu Provincial Key Research and Development Projects [BE2017693]
- Independent Project of Chengdu Research Base of Giant Panda Breeding [2020CPB-C11]
- National Key Research and Development Programs of China [2017YFC1200201]
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Analysis of pangolin metagenomic data suggests that pangolins may be intermediate hosts for SARS-CoV-2, but further sampling and analysis from various countries are needed for confirmation.
Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS-CoV-2-related virus sequences assembled in this study and those recently published indicated that pangolin SARS-CoV-2-related viruses were clustered into two sub-lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be collected and analyzed for coronavirus to elucidate whether pangolins are intermittent hosts for SARS-CoV-2.
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