Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 140, Issue 9, Pages 1691-1697Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2019.11.023
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF), Korea, the Ministry of Science and ICT, Republic of Korea [2016R1D1A1B03932512, 2017R1A6A1A03015642]
- National Research Foundation of Korea [2016R1D1A1B03932512, 22A20130000065] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Human skin acts as a barrier to protect our bodies from UV rays and external pathogens and to prevent water loss. Phenotypes of aging, or natural aging due to chronic damage, include wrinkles and the reduction of skin thickness that occur because of a loss of skin cell function. The dysregulation of autophagy, a lysosome-related degradation pathway, can lead to cell senescence, cancer, and various human diseases due to abnormal cellular homeostasis. Here, we discuss the roles and molecular mechanisms of autophagy involved in the anti-aging effects of autophagy and the relationship between autophagy and aging in skin cells.
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