Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.

Automated summary

Atopic dermatitis is a common chronic inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to its pathogenesis, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex multidirectional network that can exacerbate atopic skin disease but can also be ameliorated by targeted therapies.