Structural Diversity of Co(II) Coordination Polymers: Treatment Activity on Alzheimer's Disease Via Reducing the Accumulation of Amyloid in Brain

Two novel coordination polymers (CPs) based on Co(II) ions as nodes with the chemical formula of {Co(DBTA)(phen)(H2O)}(n)(1) (phen = 1,10-Phenanthroline and H(2)DBTA = 2,5-Dibromo-terephthalic acid) and [Co(DBTA)(bimb)](n)(2) (bimb = 1,4-bis(imidazole-1-ylmethyl)benzene) were prepared via Co(NO3)(2)center dot 6H(2)O reacting with the H(2)DBTA in the existence of distinct nitrogen-donor co-ligands (phen for the complex1and bimb for the complex2) under solvothermal conditions. Compounds1and2with novel structures were evaluated for Alzheimer's disease (AD) treatment. Serious experiments were performed and the specific mechanism for compound also was investigated. Firstly, the AD animal model was constructed in the mice, then we injected the compound1or2into mice to perform the indicated treatment at 5 mg/kg concentration. After that, the brain volume and brain weight were measured. Then, the Amyloid (A beta) content in cerebrospinal fluid was determined to assess the activity of compound. The inflammatory cytokines released into the cerebrospinal fluid was also determined with enzyme linked immunosorbent assay (ELISA) detection. Finally, the reactive oxygen species (ROS) accumulation in the cerebral cortex cells was detected.

Automated summary

Two new coordination polymers based on Co(II) ions were synthesized for the treatment of Alzheimer's disease. The compounds were evaluated through experiments on animal models, measuring brain volume and weight, determining Aβ content, assessing inflammatory cytokines, and detecting ROS accumulation.