Journal
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
Volume 31, Issue 2, Pages 624-635Publisher
SPRINGER
DOI: 10.1007/s10904-020-01713-4
Keywords
Diabetes mellitus; Nigella sativa; Silver nanoparticles; Antioxidant; Anti-inflammatory
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Funding
- Shandong University
- FONDECYT [11170155]
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The study successfully biosynthesized potential silver nanoparticles using aqueous seed extract, showing significant antibacterial, anti-inflammatory, and antidiabetic activities. The nanoparticles exhibited a high level of purity and potential for future biomedical products.
It is a well explored facts that need of biosynthesized nanomaterials has emerged for its several advantages in biomedical applications and the search for potential biosynthesized-nanomaterials is still ongoing. In this study an attempt was made to meet the requirement of potential biosynthesized-silver nanoparticles using the aqueous seed extract ofN. sativa(Bc-AgNPs). X-ray powder diffraction (XRD) confirms the biosynthesis of silver nanoparticle (supports the observation of UV-Vis spectroscopy) with face centred cubic structure. Fourier-transform infrared spectroscopy (FTIR) confirms the capping of the active ingredients of seed extract and further the average size of 34 nm was confirmed by high-resolution transmission electron microscopy (HR-TEM) and energy dispersive X-ray analysis (EDX) confirms the purity of Bc-AgNPs. Due to the capping of the active ingredients of seed extract, the Bc-AgNPs have shown significant antibacterial activity against Gram negative bacteria and at the lower concentration of 100 mu g*ml(-1)it has 89% scavenging activity against free radicals. A strong anti-inflammatory (membrane stabilization) activity towards RBCs (98% at 100 mu g*ml(-1)) was recorded when compared to the positive control (aceclofenac). In addition to the previous activities, a greater inhibition of carbohydrate hydrolyzing enzymes such as alpha-amylase, alpha-glucosidase and DPP-IV highlighted the antidiabetic potential of these green synthesized AgNPs. Overall, the efficient bioactivities of Bc-AgNPs advocates its future potential in biomedical products.
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