Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 223, Issue 11, Pages 1934-1942Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa657
Keywords
HIV-1 latency; accelerated aging; cell-associated HIV; inflammation; viral transcription
Categories
Funding
- National Institutes of Health [AG060890, AI145661]
- Boston University Genomic Science Institute
- Providence/Boston Center for AIDS Research [P30AI042853]
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Individuals infected with HIV-1 experience increased inflammation with age, but this does not result in higher levels of HIV-1 transcription. While the older group showed higher inflammation levels, they also had higher levels of cell-associated RNA, with similar levels of intact proviruses compared to the younger group.
Individuals infected with human immunodeficiency virus (HIV) 1 have increased inflammation, which has been associated with age-associated diseases. Plasma markers, cell-associated virus levels, and ability to stimulate RNA transcription in latently infected cell lines was examined in younger and older HIV-1-infected individuals with suppressed virus. Cell-associated RNA, but not intact provirus level, had positive correlation with plasma D-dimer levels. Compared with the younger group, the older group had higher D-dimer levels and a trend toward more cell-associated RNA but similar levels of intact proviruses. Even though all measured inflammatory markers were relatively higher in the older group, this greater inflammation did not induce more HIV-1 transcription in latently infected cell lines. Inflammation and HIV-1 RNA expression increase with age despite similar levels of intact infectious HIV DNA. While plasma inflammation is correlated with HIV-1 RNA expression in peripheral blood mononuclear cells, it does not induce HIV-1 transcription in latently infected cell lines.
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