4.7 Article

The Nature and Clinical Significance of Atypical Mononuclear Cells in Infectious Mononucleosis Caused by the Epstein-Barr Virus in Children

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 223, Issue 10, Pages 1699-1706

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa601

Keywords

infectious mononucleosis; atypical mononuclear cells; Epstein-Barr virus; CD8 T cells; antibody microarray

Funding

  1. Russian Ministry of Science and Higher Education [AAAA-A18-118012390247-0]

Ask authors/readers for more resources

Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM), primarily consisting of CD8(+) T cells and a small fraction of CD19(+) B lymphocytes. The AM population amount is significantly higher in children with mononucleosis caused by primary EBV infection compared to other viral infections, and the recovery from classic IM associated with primary EBV infection is correlated with the percentage of CD8(+) AM.
Atypical mononuclear cells (AM) appear in significant numbers in peripheral blood of patients with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). We investigated the number and lineage-specific clusters of differentiation (CD) expression of atypical mononuclear cells in 110 children with IM using the anti-CD antibody microarray for panning leukocytes by their surface markers prior to morphology examination. The AM population consisted primarily of CD8(+) T cells with a small fraction (0%-2% of all lymphocytes) of CD19(+) B lymphocytes. AM amount in children with mononucleosis caused by primary EBV infection was significantly higher than for IM caused by EBV reactivation or other viruses and constituted 1%-53% of all peripheral blood mononuclear cells compared to 0%-11% and 0%-8%, respectively. Children failing to recover from classic IM associated with primary EBV infection within 6 months had significantly lower percentage of CD8(+) AM compared to patients with normal recovery rate.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available