Journal
JOURNAL OF IMMUNOLOGY
Volume 205, Issue 6, Pages 1620-1632Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2000341
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [31822057]
- National Key Research and Development Project [2018YFD0900503]
Ask authors/readers for more resources
Upon recognition of bacterial or viral components by pattern recognition receptors, cells could be activated to produce inflammatory cytokines, type I IFN, and IFN-stimulated genes. These antibacterial and antiviral immunities are tightly regulated by the host to prevent inappropriate immune responses. MicroRNAs (miRNAs) have emerged as an essential regulatory network with profound effects on mammalian inflammation and immune responses, but the regulatory networks of miRNA-mediated immune response in lower vertebrates remain largely unknown. In this study, we report a miRNA, miR-217, identified from miiuy croaker, which plays a negative role in host antiviral and antibacterial immunity. We found that miR-217 could be abundantly expressed upon Gram-negative bacteria, as well as rhabdovirus infection. Inducible miR-217 suppresses the production of inflammatory cytokines and type I IFN by targeting TAK1, thereby avoiding excessive inflammation. Particularly, we revealed that miR-217 modulates the antibacterial and antiviral immunity through TAK1-mediated NF-kappa B and IRF3 signaling pathways. The collective results indicate that miR-217 acts as a negative feedback regulator involved in host antibacterial and antiviral immune responses, which will provide insights into the intricate networks of host-virus interaction in lower vertebrates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available