Journal
JOURNAL OF IMMUNOLOGY
Volume 205, Issue 7, Pages 1721-1730Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2000612
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Funding
- National Institutes of Health [AI134972]
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CD4(+) Th cells are responsible for orchestrating diverse, pathogen-specific immune responses through their differentiation into a number of subsets, including T(H)1, T(H)2, T(H)9, T follicular helper, T follicular regulatory, and regulatory T cells. The differentiation of each subset is guided by distinct regulatory requirements, including those derived from extracellular cytokine signals. IL-2 has emerged as a critical immunomodulatory cytokine that both positively and negatively affects the differentiation of individual Th cell subsets. IL-2 signals are propagated, in part, via activation of STAT5, which functions as a key regulator of CD4(+) T cell gene programs. In this review, we discuss current understanding of the mechanisms that allow IL-2-STAT5 signaling to exert divergent effects across CD4(+) T cell subsets and highlight specific roles for this pathway in the regulation of individual Th cell differentiation programs.
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