Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 396, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.122693
Keywords
Freshwater; Size; Accumulation; Metabolomics; Integrated biomarker response
Categories
Funding
- National Natural Science Foundation of China [51809118, 61773181]
- Natural Science Foundation of Jiangsu Province, China [BK20170188]
- Postdoctoral Science Foundation of China [2019M651704]
- State Key Laboratory of Pollution Control and Resource Reuse Foundation [PCRRF18038]
- Fundamental Research Funds for the Central Universities [JUSRP1902XNC]
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Nanoplastics (NPs) and microplastics (MPs) are a heterogeneous class of pollutants with diverse sizes in aquatic environments. To evaluate the hazardous effects of N/MPs with different sizes, the accumulation, oxidative stress, cytochrome P450 (CYP) enzymes, neurotoxicity, and metabolomics changes were investigated in the red tilapia exposed to three sizes of polystyrene (PS) N/MPs (0.3, 5, and 70 - 90 mu m). After 14-d exposures, the largest particles (70 - 90 mu m) showed the highest accumulation levels in most cases. Exposures to PS-MPs (5 and 70 - 90 mu m) caused a more severe oxidative stress in red tilapia than PS-NPs. The activity of CYP3A-related enzyme was obviously inhibited by PS-NPs, whereas the CYP enzymes in the liver may not be sensitive to MP exposures. In the brain, only 5 mu m PS-MPs significantly inhibited the acetylcholinesterase activity. After exposures, the treatments with 0.3, 5, and 70 - 90 mu m N/MPs resulted in 31, 40, and 23 significantly differentially expressed metabolites, respectively, in which the pathway of tyrosine metabolism was significantly affected by all the three PS-N/MP exposures. Overall, the PS particles within the pm size posed more severe stress to red tilapia. Our results suggest that the toxicity of N/MPs may not show a simply monotonic negative correlation with their sizes.
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