Journal
JOURNAL OF FLUORESCENCE
Volume 31, Issue 1, Pages 85-90Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10895-020-02638-4
Keywords
Nitrogen and sulfur-carbon quantum dots; Eplerenone; Fluorescence; Nanosensor; Human plasma
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A novel ecofriendly optical nanosensor for detecting Eplerenone (EPL) in biological samples was reported in this study. Highly luminescent N, S-CQDs were successfully prepared and used as a fluorescent probe for sensitive determination of EPL. The method showed promising results in drug formulations and spiked human serum samples.
In this work, a novel ecofriendly optical nanosensor for detection of Eplerenone (EPL) in biological samples was reported. Highly luminescent water-soluble nitrogen and sulfur doped carbon quantum dots (N, S-CQDs) have been prepared successfully. The synthesis was based on the reaction of thiosemicarbazide (TS) as source of N and S and citric acid (CA) as source of carbon in one-step aqueous base reflux treatment. The produced N, S-CQDs have a small particle size in the range of 4.7 nm with a high quantum yield (58.5%) and high emission intensity at 446 nm under excitation wavelength of 370 nm. The unique properties of N, S-CQDs make them useful tool as a nano fluorescent probe for sensitive determination of EPL. EPL has been found to decrease the fluorescence of S, N-CDs significantly through static quenching according to the Stern - Volmer plot. The decreased intensity of S, N-CDs fluorescence was proportional to EPL in the 0.2-3.0 mu M range. The limit of detection and quantitation were 0.05 and 0.15 mu M, respectively. The assay of EPL by this approach was successfully done in drug formulations and in spiked human serum samples.
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