Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 12, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20200872
Keywords
-
Categories
Funding
- Agence Nationale de la Recherche JCJC program [ANR-19-CE15-0032-01]
- Fondation du Souffle
- Fonds de Recherche en Sante Respiratoire
- Institut national de la sante et de la recherchemedicale
- Centre Hospitalier Regional Universitaire de Tours
- University of Tours
Ask authors/readers for more resources
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, gamma delta T, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available