Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 61, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jddst.2020.102135
Keywords
Nanocarrier; Metal-organic frameworks; Adenosine; Drug protection; In vitro release
Categories
Funding
- Vietnam Ministry of Science and Technology [DTDL.CN-03/19]
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Nanoscale Zn-based MOF nanoparticles were synthesized successfully in this study using PVP as a modulator, exhibiting high crystallinity, porosity, and stable structure. The material showed potential as a high-capacity nanocarrier for adenosine, with excellent adsorption kinetics and release profile in vitro.
Nanoscale metal-organic frameworks (MOFs) have been a steady growing interest worldwide in biomedical applications, especially in drug carriers. Adenosine, an unstable nucleoside composed of adenine and D-ribose, plays many important biological roles and recently used in many treatments. In this study, Zn-based MOF nanoparticles were successfully synthesized in large-scale by using polyvinylpyrrolidone (PVP) as a modulator for controlling the particle size, and characterized for efficient incorporation and protection of adenosine. Nano MOF displayed homogeneously polyhedral crystals with particle size smaller than 50 nm. According to X-ray diffraction, N-2 isotherm sorption, and thermogravimetric analysis characterizations, the nano material has high crystallinity, high porosity, and stable structure. Moreover, investigation of adenosine encapsulation onto nano MOF showed that the material was a high potential for nanocarrier with high loading capacity up to 833 mg g(-1). The kinetics and mechanism studies reveal the adenosine adsorption of MOF fit well with the pseudo-second-order model and Langmuir model. The in vitro release profile of the adenosine/nano MOF sample shows the presence of adenosine in phosphate-buffered saline solution, exhibiting the adenosine protection role of the nanocarrier.
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