Journal
JOURNAL OF CONTROLLED RELEASE
Volume 325, Issue -, Pages 52-71Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.06.032
Keywords
Photodynamic therapy; Photothermal therapy; Microneedles; Nano-materials; Controlled release
Funding
- National High-Tech Research and Development Program of China [2014AA020707]
- National Natural Science Foundation of China [21503035, 21606041, 21776044]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
Microneedles (MNs), as an effective minimally invasive delivery route, when used to puncture the skin, can bypass the skin's stratum corneum (SC) to enter the skin microcirculation and achieve systemic administration. Additionally, the MN route has obvious advantages over other routes of administration, including simplicity, non-pain, readily-permitted transport of drugs (including DNA and metformin) and macromolecules (such as antibodies and proteins), good repeatability, and wide range of clinical applications and safety. MNs have been combined with various therapy strategies including photodynamic therapy (PDT) and photothermal therapy (PTT) to treat many diseases, and hold great promise for improving the diagnosis and treatment of diseases. Both MN-assisted PDT and PTT are light-mediated phototherapy methods and have unique advantages, including improved selectivity, and minimal invasiveness and side effects. MN-assisted PDT or PTT has been studied for various applications by many research groups and pharmaceutical companies worldwide. Therefore, this review summarizes recent advances in MNs for PDT or PTT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available