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Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Ligand-targeted liposome design: challenges and fundamental considerations
Gavin T. Noble et al.
TRENDS IN BIOTECHNOLOGY (2014)
Nanomedicine therapeutic approaches to overcome cancer drug resistance
Janet L. Markman et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes
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ADVANCED MATERIALS (2013)
Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy
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BIOMATERIALS (2013)
Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice
Darren Lars Stirland et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors
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MOLECULAR THERAPY (2013)
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Tracy R. Daniels et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)
Regulation of iron transport and the role of transferrin
Konstantinos Gkouvatsos et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)
U.S. Food and Drug Administration Approval Summary: Brentuximab Vedotin for the Treatment of Relapsed Hodgkin Lymphoma or Relapsed Systemic Anaplastic Large-Cell Lymphoma
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CLINICAL CANCER RESEARCH (2012)
On the cellular processing of non-viral nanomedicines for nucleic acid delivery: Mechanisms and methods
Dries Vercauteren et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Doxil® - The first FDA-approved nano-drug: Lessons learned
Yechezkel (Chezy) Barenholz
JOURNAL OF CONTROLLED RELEASE (2012)
Immunoliposomal delivery of doxorubicin can overcome multidrug resistance mechanisms in EGFR-overexpressing tumor cells
Christoph Mamot et al.
JOURNAL OF DRUG TARGETING (2012)
Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study
Christoph Mamot et al.
LANCET ONCOLOGY (2012)
Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study
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LANCET ONCOLOGY (2012)
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
Peter D. Senter et al.
NATURE BIOTECHNOLOGY (2012)
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
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NATURE NANOTECHNOLOGY (2012)
Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
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NEW ENGLAND JOURNAL OF MEDICINE (2012)
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
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SCIENCE TRANSLATIONAL MEDICINE (2012)
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Pegylated Liposomal Doxorubicin A Review of its use in Metastatic Breast Cancer, Ovarian Cancer, Multiple Myeloma and AIDS-Related Kaposi's Sarcoma
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DRUGS (2011)
Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increased in vivo activity
Jerzy Gubernator
EXPERT OPINION ON DRUG DELIVERY (2011)
Hyaluronan-CD44 interactions as potential targets for cancer therapy
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FEBS JOURNAL (2011)
Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2) -Positive Breast Cancer After Prior HER2-Directed Therapy
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JOURNAL OF CLINICAL ONCOLOGY (2011)
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
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JOURNAL OF CONTROLLED RELEASE (2011)
Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes
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JOURNAL OF DRUG TARGETING (2011)
Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA
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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules
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NATURE MEDICINE (2011)
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BIOMATERIALS (2010)
CD44, a therapeutic target for metastasising tumours
Veronique Orian-Rousseau
EUROPEAN JOURNAL OF CANCER (2010)
Safety, Pharmacokinetics, and Preliminary Clinical Activity of Inotuzumab Ozogamicin, a Novel Immunoconjugate for the Treatment of B-Cell Non-Hodgkin's Lymphoma: Results of a Phase I Study
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JOURNAL OF CLINICAL ONCOLOGY (2010)
Phase I Study of Trastuzumab-DM1, an HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer
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JOURNAL OF CLINICAL ONCOLOGY (2010)
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
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NATURE (2010)
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NEW ENGLAND JOURNAL OF MEDICINE (2010)
Polymer therapeutics: Clinical applications and challenges for development Preface
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ADVANCED DRUG DELIVERY REVIEWS (2009)
Polymersome delivery of siRNA and antisense oligonucleotides
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JOURNAL OF CONTROLLED RELEASE (2009)
The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
Mark E. Davis
MOLECULAR PHARMACEUTICS (2009)
Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
Gail D. Lewis Phillips et al.
CANCER RESEARCH (2008)
Effective anti-tumor activity of oxaliplatin encapsulated in transferrin-PEG-liposome
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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)
Impact of single-chain fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells
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JOURNAL OF MOLECULAR BIOLOGY (2007)
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo
Jeremy D. Heidel et al.
CLINICAL CANCER RESEARCH (2007)
Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles
Derek W. Bartlett et al.
BIOCONJUGATE CHEMISTRY (2007)
Polymer therapeutics: Concepts and applications
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
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CANCER RESEARCH (2005)
Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer
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ANNALS OF ONCOLOGY (2004)
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BRITISH JOURNAL OF CANCER (2003)
Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
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JOURNAL OF NEURO-ONCOLOGY (2003)
The dawning era of polymer therapeutics
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NATURE REVIEWS DRUG DISCOVERY (2003)
Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
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BIOCONJUGATE CHEMISTRY (2002)
Mylotarg: antibody-targeted chemotherapy comes of age
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CURRENT OPINION IN ONCOLOGY (2001)
Preclinical evaluation of the cardiotoxicity of PK2: A novel HPMA copolymer-doxorubicin-galactosamine conjugate antitumour agent
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HUMAN & EXPERIMENTAL TOXICOLOGY (2001)