Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 585, Issue -, Pages 676-683Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2020.10.047
Keywords
Cell viability assay; AgNPs; Periodic mesoporous organosilica (PMO); Urea-based PMO (Ur-PMO); Antibacterial activity
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Funding
- Maragheh University of Medical Sciences [1.857d.64, IR.MARAGHEHPHC.REC.1398.012]
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Nano-size silver particles stabilized on urea-based periodic mesoporous organosilica, using Euphorbia leaf extract as a green reducing agent; physical and chemical properties of organosilica materials analyzed through various techniques; promising biocompatibility and antibacterial effects of designed material demonstrated through in vitro cytotoxicity test.
Nano-size silver particles were stabilized on the inner surfaces of urea based periodic mesoporous organosilica (Ur-PMO). Aqueous extract of Euphorbia leaves as a sustainable and green reducing agent was applied for Ag-nanoparticles growth into the Ur-PMO channels. Physical and chemical properties of organosilica materials synthesized using various techniques such as FT-IR, small-angle XRD, PXRD, FESEM, TEM, SEM-EDX and atomic absorption spectrometry (AAS) were examined. Finally, the AgNPs/Ur-PMO were investigated on cell viability assay. An in vitro cytotoxicity test using MMT assay displayed that the designed material has good biocompatibility and could be a promising candidate for biomedical applications. The results also showed that the AgNPs/Ur-PMO compounds (especially, PMO; 1.27% AgNPs) had relatively good antibacterial and antibiofilm effects. It seems that the use of these compounds in hospital environments can reduce nosocomial infections as well as reduce antibiotic-resistant bacteria. (C) 2020 Elsevier Inc. All rights reserved.
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