Effect of Magnesium Substitution on Structural, Magnetic and Biological Activity of Co(1-x)Mg(x)Fe2O4Nano-colloids

Citrate coated magnesium substituted cobalt ferrite nanoparticles Co(1-x)Mg(x)Fe2O4(where, x = 0.0, 0.25, 0.50, 0.75, 1.0) were prepared by sonochemical method. X-ray diffraction, energy dispersive X-ray analysis, scanning electron microscopy and Fourier transform infrared spectroscopy results confirmed the formation of spinel structures for all concentration values of substitution (x = 0.0-1.0). Furthermore, saturation magnetization was decreased upon increasing magnesium content. Hemolysis assay in vitro confirmed safety of nanoparticles for systemic administration and was non-significant upon increasing magnesium content when compared to untreated control. In vitro cytotoxicity screening against HepG2 cells revealed that cytotoxicity had an inverse relation with increasing magnesium concentration. Highly significant result was observed in the presence of x = 0.25 with percentage viability of 33.5 +/- 2.28%. Similarly, antibacterial studies showed highly significant bacterial inhibition against pathogenic strains in the presence of x = 0.25. The results reveal the optimal value of magnesium co-doped functional magnetic materials and their application in biomedicine.

Automated summary

The research findings suggest that the optimal value for magnesium co-doped functional magnetic materials is x = 0.25, which shows potential in biomedical applications with significant hemolytic, cytotoxic, and antibacterial activities.