Journal
JOURNAL OF CLUSTER SCIENCE
Volume 32, Issue 6, Pages 1519-1529Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-020-01908-2
Keywords
AgNPs@Cu; GMP; Stability; Antimicrobial activity; MIC
Categories
Funding
- National Natural Science Foundation of China [21878014]
- Beijing Natural Sciences Foundation [2162030]
- Beijing Municipal Education Commission [KZ201710020014]
- 111 Project [B13005]
- Double First-rate Program [ylkxj03]
Ask authors/readers for more resources
Silver nanoparticles encapsulated into copper and guanosine 5'-monophosphate (Cu/GMP) metal organic frameworks were successfully synthesized at room temperature without using any external stimuli. Compared to pure AgNPs, the composite material AgNPs@Cu/GMP showed significant antimicrobial activity and stability, making it a promising candidate for pharmaceutical and biomedical applications.
Silver nanoparticles (AgNPs) are effective antibacterial agent but lack of stability and rapid aggregation limits their antibacterial efficiency in biomedical applications. To overcome these shortcomings, various strategies have been adopted so far but those strategies are not much effective at room temperature and in absence of external stimuli. Thus, herein, we have successfully grafted AgNPs into copper and guanosine 5 '-monophosphate (Cu/GMP) metal organic frameworks at room temperature without using any external stimuli. The loading encapsulation ratio of AgNPs into Cu/GMP was approx. 99.83% at neutral pH. The AgNPs@Cu/GMP was characterized by various techniques, such as energy-dispersive x-ray spectroscopy, transmission electron microscopy, x-ray diffraction and Fourier transforms infrared spectroscopy. All these techniques have confirmed the loading of AgNPs into Cu/GMP (MOFs). Furthermore, antimicrobial activities of AgNPs, Cu/GMP and AgNPs@Cu/GMP were assessed againstEscherichia coli(Gram-negative) andStaphylococcus aureus(Gram-positive) bacterium. As compared to pure AgNPs, the composite material AgNPs@Cu/GMP had shown significant growth of inhibition zones against tested bacteria. The stability of AgNPs@Cu/GMP was remarkable, i.e., six times higher than free AgNPs even after 15 days. These results make AgNPs encapsulated into Cu/GMP a promising antimicrobial candidate and is expected to deliver an advance platform to pharmaceuticals and biomedical applications. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available