Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 32, Issue 1, Pages 60-75Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1816110
Keywords
GT; PCL; coaxial electrospun; skin regeneration; nanofiber
Funding
- China Medical Association-L'OREAL Skin Hair Grant [S2017140912]
- Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine [JYJC201901]
- Youth Program of National Natural Science Foundation of China [81401532]
Ask authors/readers for more resources
In this study, a novel nano-scale material ES-GT/PCL nanofiber was fabricated using coaxial electrospinning technique, which possessed a highly porous structure and qualified mechanical properties for transplantation. By adding multiple bioactive factors to nanometre biomaterials, it optimized the advantages of compositions as a promising potential dermal substitute construct, promoting cell proliferation and accelerating skin wound healing rate.
In this study, an ideal nano-scale material, named epidermal stimulating (ES) factors-gelatin/polycaprolactone (GT/PCL) nanofiber, was fabricated using a coaxial electrospinning technique. The ES-GT/PCL nanofibers possessed a highly porous structure with qualified mechanical properties for transplantation. With ES factors stored in the core and GT/PCL in the shell, the ES factors could be protected and released in a sustained manner. After seeding L929 cell line on ES-GT/PCL nanofibers for 7 daysin vitro, the proliferation of cells was nearly 1.5 folds compared to the control group. Thein vivostudy showed that ES-GT/PCL nanofibers can accelerate skin wound healing rate during the healing course, especially on the early stage. The epidermal and dermal thickness, as well as skin appendages and fat tissue, were the most similar to the native skin. These findings provided valuable insights into the addition of multiple bioactive factors to nanometre biomaterials, and optimising the advantages of the compositions as a promising potential dermal substitute construct.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available