Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 35, Issue 7, Pages 857-868Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328220952594
Keywords
Cell membrane mimetic polymer; chitosan; controlled drug release; cellular fluorescence imaging
Funding
- National Natural Science Foundation of China [21304075]
- China Scholarship Council [201706970002]
- Natural Science Basic Research Plan in Shaanxi Province of China [2020JM-420]
- Wisteria Scientific Research Cooperation Special Project
- Top-rated Discipline construction scheme of Shaanxi higher education
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The study successfully fabricated gold embedded chitosan nanoparticles with precise control over their size and distribution by modifying molecules including PMPC.
In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.
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