Hyperbranched poly(glycerol esteramide): A biocompatible drug carrier from glycerol feedstock and dicarboxylic acid

Polymer carrier with biodegradable, biocompatible as well as solubility enhancing properties are highly looked upon in the pharmaceutical industry to improve the drug delivery systems. A series of hyperbranched poly(glycerol esteramide) (HPGEA) withM(w)of 5000-12,000 Da, degree of branching of 57%-62%, and hydroxyl values of 200-280 mg KOH/g sample were synthesized through polycondensation of N,N-bis(2-hydroxyethyl)stearamide (diethanolamide) and poly(glycerol ester) (PGE). The HPGEAs were characterized by ATR-FTIR, GPC,H-1 and(13)C-NMR, and DSC. The enthalpy of fusion of HPGEAs (43-84 J g(-1)) were lower than the commercial polymers (193-391 J g(-1)), indicating its potential as drug carrier for solid dispersion (SD). HPGEA-based SDs showed substantial enhancement in solubility and release rate than pure drug, commercial polymer-based SDs, as well as commercial formulation. The safety of HPGEAs and HPGEA-based SDs were proven through MTT assay with IC(50)of 2400-9800 and 1200-3500 mu g ml(-1), respectively.

Automated summary

Hyperbranched poly(glycerol esteramide) (HPGEA) with biodegradable, biocompatible, and solubility enhancing properties is highly promising in drug delivery systems. Compared to commercial polymers, HPGEA exhibits lower enthalpy of fusion, making it a potential drug carrier for solid dispersion (SD) to enhance drug solubility and release rate. The safety of HPGEA and HPGEA-based SDs was confirmed through MTT assay, with IC(50) values indicating their cytotoxicity levels.