Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 75, Issue 12, Pages 3635-3643Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkaa364
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Funding
- Acurx Pharmaceuticals
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Background: Clostridioides difficile infection is the most common cause of healthcare-associated infections in the USA, with Limited treatment options. Ibezapolstat is a novel DNA polymerase IIIC inhibitor with in vitro activity against C. difficile. Objectives and methods: Randomized, double-blind, placebo-controlled study to assess the safety, tolerability and pharmacokinetics of ibezapolstat in healthy volunteers. Microbiome changes associated with ibezapolstat were compared with vancomycin over a 10 day course using shotgun metagenomics. Results: A total of 62 subjects aged 31 +/- 7 years (45% female; average BMI: 25 +/- 3 kg/m(2)) were randomized. Ibezapolstat was well tolerated with a safety signal similar to placebo. Ibezapolstat had minimal systemic absorption with the majority of plasma concentrations Less than 1 mu g/mL. In the multiday, ascending dose study, ibezapolstat concentrations of 2000 mu g/g of stool were observed by Day 2 and for the remainder of the dosing time period. In the multiday, multiple-dose arm, baseline microbiota was comparable between subjects that received ibezapolstat compared with vancomycin. At Day 10 of dosing, differential abundance analysis and beta-diversity demonstrated a distinct difference between the microbiome in subjects given vancomycin compared with either dose of ibezapolstat (P= 0.006). alpha-Diversity changes were characterized as an increase in the Actinobacteria phylum in subjects that received ibezapolstat and an increase in Proteobacteria in subjects given vancomycin. Conclusions: Ibezapolstat was shown to be safe and well tolerated, with minimal systemic exposure, high stool concentrations and a distinct microbiome profile compared with oral vancomycin. These results support further clinical development of ibezapolstat for patients with C. difficile infection.
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