Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 36, Pages 9697-9706Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c03396
Keywords
2-methoxy-1,4-naphthoquinone; Penicillium digitatum; omics; branched-chain amino acids; cell wall; mechanism
Funding
- Science and Technology Planning Project of Guangdong Province [2017A020217002]
- Program of Department of Natural Resources of Guangdong Province [GDME2018C014, GDNRC[2020]038]
- Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams [2019KJ122]
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Penicillium digitatum is the primary pathogen causing the green mold of citrus. The need for the development of higher effective and lower toxic natural antifungal agents is urgent, owing to the lack of antifungal agents that can successfully combat P. digitatum. Herein, the effects and mechanisms of 2-methoxy-1,4-naphthoquinone (MNQ) as a potential inhibitor of P. digitatumwere studied. First, MNQ showed a significant anti-P. digitatum effect with a minimum inhibitory concentration value of 5.0 mu g/mL. Then, transcriptome, proteome, and metabolome profiling were performed on the MNQ-treated P. digitatum. A total of 910 genes, 297 proteins, and 174 metabolites changed significantly. The omics analysis indicated that it could be seen that MNQ mainly inhibits the growth of P. digitatum by affecting the synthesis of branched-chain amino acids and cell walls. These findings will be a great contribution to the further understanding of the possible molecular action of MNQ.
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