Journal
JAPANESE JOURNAL OF RADIOLOGY
Volume 39, Issue 1, Pages 40-46Publisher
SPRINGER
DOI: 10.1007/s11604-020-01030-3
Keywords
Antisynthetase syndrome; HRCT; Acute interstitial pneumonia
Funding
- Universita degli Studi di Trieste
Ask authors/readers for more resources
Antisynthetase syndrome (ASS) is a rare autoimmune condition associated with anti-aminoacyl-tRNA synthetase antibodies, often presenting as interstitial lung disease (ILD). HRCT findings in ASS-associated ILD are typically non-specific, but should be considered in patients with acute onset of symptoms.
Purpose Antisynthetase syndrome (ASS) is a rare systemic autoimmune condition associated to the presence of anti-aminoacyl-tRNA synthetase antibodies. Interstitial lung disease (ILD) is the most prevalent manifestation of ASS and is a major determinant of morbidity and mortality. The aim of this study was to describe the radiological characteristics of patients with ASS-associated-ILD in our institution. Materials and methods Medical records from 2014 to 2020 were retrospectively reviewed and patients with a diagnosis of ASS and evidence of ILD on HRCT were included. HRCT images were reviewed by two thoracic radiologists in consensus. Five HRCT patterns were defined: cellular non-specific interstitial pneumonia (NSIP), organizing pneumonia (OP), mixed NSIP/OP pattern, acute interstitial pneumonia (AIP) pattern and fibrotic pattern. Descriptive statistics was calculated for all variables. Results Twenty-two patients with ASS who met inclusion criteria were included. The disease presented with the typical triad of ASS in 45% of patients, 55% had ILD only at the onset. Cellular NSIP was present in 27% of patients, OP in 23%, mixed NSIP/OP in 9%, AIP in 18% and a fibrotic pattern in 23%. Conclusion HRCT findings in ASS-associated ILD are often non-specific; nevertheless, it is important to consider this diagnosis, especially in patients presenting with acute onset of symptoms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available