Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 71, Issue 2, Pages 139-147Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1809407
Keywords
Drug release behavior; hexachlorocyclotriphosphazene (HCCP); nanospheres; piperazine
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In this study, poly(cyclotriphosphazene-co-piperazine) p(HCCP-co-PIP) nanospheres were prepared and confirmed through various characterization methods. The experimental results demonstrated that p(HCCP-co-PIP) nanospheres exhibited excellent drug release properties, suggesting their potential as drug delivery carriers.
In this study, poly(cyclotriphosphazene-co-piperazine) p(HCCP-co-PIP) nanospheres were prepared. The successful preparation of the p(HCCP-co-PIP) nanospheres was confirmed by FT-IR, SEM, TEM, XRD, TGA and DLS, respectively. The prepared p(HCCP-co-PIP) nanospheres were used for drug delivery system. The model drug doxorubicin (DOX) was loaded in p(HCCP-co-PIP) nanospheres. The drug release properties of the p(HCCP-co-PIP) nanospheres were investigated in pH 4.0 and pH 7.4. The cumulative release was found to be 86.2% in pH 4.0 and 54.7% in pH 7.4 at 37 degrees C after 216 h. The obtained result suggested that the nanospheres could be used as drug carriers.
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