Journal
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 1, Pages 1-7Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ijnp/pyaa066
Keywords
Treatment discontinuation; lipid metabolism; weight gain; medication-naive; second-generation antipsychotic
Funding
- Instituto de Salud Carlos III [PI020499, PI050427, PI060507]
- Valdecilla Insitute of Biomedical Research [NVAL17/24]
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Discontinuing antipsychotic treatment in patients with first episode psychosis resulted in lower weight gain and better metabolic parameters at the 10-year follow-up, although the effects were not sufficient for complete reversal to normal levels.
Background: Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort. Methods: A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected. Results: Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up. Conclusions: Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.
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