Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 15, Issue -, Pages 8109-8119Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S258625
Keywords
nanomedicine; cancer therapy; pH-responsive; co-delivery; PLK1
Funding
- US Department of Agriculture [2015-38422-24059]
- National Institutes of Health [R01AI135005]
- NIFA [810347, 2015-38422-24059] Funding Source: Federal RePORTER
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Background: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects. Methods: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release. Results: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC50 value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model. Conclusion: This study may provide an adaptable, facile platform to investigate drugsiRNA combinations for cancer inhibition.
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