4.7 Article

Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43

Related references

Note: Only part of the references are listed.
Review Neurosciences

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Archana Prasad et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Isolation and characterization of soluble human full-length TDP-43 associated with neurodegeneration

Mirella Vivoli Vega et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43

Hao-Ru Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2018)

Article Biochemistry & Molecular Biology

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing

Ailin Wang et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

Edoardo Del Poggetto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories

Supratik Sen Mojumdar et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

The N-terminal dimerization is required for TDP-43 splicing activity

Lei-Lei Jiang et al.

SCIENTIFIC REPORTS (2017)

Article Chemistry, Multidisciplinary

The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding

Phoebe S. Tsoi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Phase to Phase with TDP-43

Yulong Sun et al.

BIOCHEMISTRY (2017)

Article Biochemistry & Molecular Biology

The TDP-43 N-terminal domain structure at high resolution

Miguel Mompean et al.

FEBS JOURNAL (2016)

Article Chemistry, Multidisciplinary

A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity

Theodoros K. Karamanos et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Biochemistry & Molecular Biology

Systemic Amyloidosis: Lessons from β2-Microglobulin

Monica Stoppini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

Andras Micsonai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis

Edoardo Del Poggetto et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

Pan-Hsien Kuo et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

Petur O. Heidarsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

Haina Qin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

Yong-Jie Zhang et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

Peter J. Lukavsky et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

Chung-ke Chang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Identification of a Conserved Aggregation-Prone Intermediate State in the Folding Pathways of Spc-SH3 Amyloidogenic Variants

H. Krobath et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Structure of an Intermediate State in Protein Folding and Aggregation

Philipp Neudecker et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

The Seeds of Neurodegeneration: Prion-like Spreading in ALS

Magdalini Polymenidou et al.

Editorial Material Clinical Neurology

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

Ian R. A. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2010)

Review Biochemistry & Molecular Biology

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Clotilde Lagier-Tourenne et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

Chantelle F. Sephton et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Clinical Neurology

TDP43-Positive Intraneuronal Inclusions in a Patient with Motor Neuron Disease and Parkinson's Disease

Jean-Baptiste Chanson et al.

NEURODEGENERATIVE DISEASES (2010)

Article Biochemistry & Molecular Biology

TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons

Inigo Casafont et al.

JOURNAL OF STRUCTURAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

Pan-Hsien Kuo et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Clinical Neurology

Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

Claudia Schwab et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Multidisciplinary Sciences

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

Youhna M. Ayala et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

Jemeen Sreedharan et al.

SCIENCE (2008)

Article Neurosciences

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43

Yong-Jie Zhang et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Biochemical Research Methods

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC

Mamie Z. Li et al.

NATURE METHODS (2007)

Article Biochemistry & Molecular Biology

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Multidisciplinary Sciences

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Manuela Neumann et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

An obligatory intermediate in the folding pathway of cytochrome c552 from Hydrogenobacter thermophilus

C Travaglini-Allocatelli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Human, Drosophila, and C-elegans TDP43:: Nucleic acid binding properties and splicing regulatory function

YM Ayala et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

The Microprocessor complex mediates the genesis of microRNAs

RI Gregory et al.

NATURE (2004)