Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms21165904
Keywords
autism spectrum disorder (ASD); miRNA; miRNA target; biomarkers; therapy
Funding
- National Natural Science Foundation of China [31760314]
- Ministry of Science and Technology of China [2018YFA0108502]
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Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.
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