Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms21186502
Keywords
intestinal permeability; colon; drug delivery; inflammatory bowel diseases
Funding
- Spanish Government [RTI2018-100910-B-C41]
- Generalitat Valenciana [PROMETEO/2018/024]
- project MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA - Agencia Estatal Investigacion [SAF2016-78756]
- European Union, through FEDER (Fondo Europeo de Desarrollo Regional)
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Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.
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