Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 46, Issue 5, Pages 1695-1706Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2020.4725
Keywords
ginsenoside Rh2; apoptosis; mitochondrial metabolism; voltage-dependent anion channel 1; cervical cancer
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Funding
- National Key Research and Development program of China [2017YFC1702104]
- National Natural Foundation of China [81703663]
- Key Project At Central Government Level: The Ability Establishment of Sustainable Use For Valuable Chinese Medicine Resources [2060302]
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20(S) -Ginsenoside Rh2 [20(S)-GRh2], one of the main active components of Panax ginseng, induces apoptosis in a wide range of cancer cell types. The present study found that 20(S)-GRh2 reduces mitochondrial membrane potential, decreases adenosine triphosphate generation and induces reactive oxygen species in HeLa cervical cancer cells. In addition, 20(S)-GRh2 activated mitochondrion-dependent apoptosis and inhibited both mitochondrial oxidative phosphorylation and glycolysis in HeLa cells. It was found that voltage-dependent anion channel 1 (VDAC1) expression was significantly upregulated by 20(S)-GRh2 treatment, while hexokinase 2 expression was downregulated and segregated from the mitochondria. Furthermore, 20(S)-GRh2 promoted Bax transport from the cytoplasm to the mitochondria, and knockdown of VDAC1 inhibited Bax transport and apoptosis. These results suggest that VDAC1 is a novel target of 20(S) -GRh2. The present study provides a better understanding of the mechanistic link between cervical cancer metabolism and growth control, and these results may facilitate the development of new treatments for cervical cancer.
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