Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 148, Issue 4, Pages 1006-1013Publisher
WILEY
DOI: 10.1002/ijc.33291
Keywords
biomarkers; diagnosis; metastasis; pancreatic cancer; prediction
Categories
Funding
- National Natural Science Foundation of China [81802432, 81802433]
- Natural Science Foundation of Tianjin [18JCZDJC32600]
- College subject Foundation of Tianjin Medical University Cancer Institute and Hospital [Y1710]
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LIF overexpression in pancreatic tumor tissues is associated with poorer overall survival and recurrence-free survival. Higher serum LIF levels in pancreatic cancer patients are more effective in predicting lymph node and distant metastasis compared to other biomarkers.
Pancreatic cancer has a low survival rate, and most patients have lymph node metastasis and distant metastasis at the time of diagnosis. Despite efforts to improve overall survival (OS) and recurrence free survival (RFS), the prognosis of pancreatic cancer remains poor, underscoring the importance of identifying new biomarkers to predict metastasis in patients with pancreatic cancer. Leukemia inhibitory factor (LIF) is overexpressed in many types of cancer and is involved in the development of various malignancies including pancreatic cancer. However, the role of LIF as a biomarker to predict metastasis in pancreatic cancer remains unclear. In this study, univariate and multivariate Cox regression analyses identified LIF expression in pancreatic tumor tissues as an independent risk factor related to worse OS and RFS. LIF overexpression was related to poor clinicopathological features such as lymph node metastasis and Pathological stage (pTNM) stage. Serum LIF levels were higher in pancreatic cancer patients than in healthy controls. The area under the receiver operating characteristic curve indicated that serum LIF is more effective than other biomarkers (CA199 and CEA) for predicting lymph node and distant metastasis.
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