Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 159, Issue -, Pages 704-713Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.05.083
Keywords
Codonopsis stem polysaccharides; Structural characterization; Antioxidant activity
Funding
- International Cooperation Projects of Science and Technology Department of Sichuan Province [2017HH0093]
- China Postdoctoral Science Foundation [2016M602704]
- Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System [SCCXTD-2020-18]
- Research Council of Norway through the Norwegian NMR Platform, NNP [226244/F50]
- Key Laboratory of Animal Disease and Human Health of Sichuan Province
- Department of Pharmacy, section Pharmaceutical chemistry, University of Oslo
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In this study, two pectic polysaccharides from stems of Codonopsis pilosula (CPSP-1) and C. tangshen (CTSP-1) were obtained by ion exchange chromatography and gel filtration. The molecular weight of CPSP-1 and CTSP-1 were 13.1 and 23.0 kDa, respectively. The results of structure elucidation indicated that both CPSP-1 and CTSP-1 are pectic polysaccharides with long homogalacturonan regions (HG) (some of galacturonic acid units were methyl esterified) and rhamnogalacturonan I (RG-I) regions. Side chains for CTSP-1 are both arabinogalactan type I (AG-I) and type II (AG-II), while CPSP-1 only has AG-II. The biological test demonstrated that CPSP-1 and CTSP-1 displayed an antioxidant property through mediating the intestinal cellular antioxidant defense sys-tem, which could protect cultured intestinal cells from oxidative stress induced oxidative damages and cell via-bility suppression. CPSP-1 and CTSP-I showed different bioactivities and mechanisms, which may be due to the difference in their structures. (C) 2020 Elsevier B.V. All rights reserved.
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