Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 159, Issue -, Pages 231-235Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.04.269
Keywords
Chaetomium globosum CGMCC 6882; Polysaccharide; Antibacterial mechanism
Funding
- Natural Science Foundation of Henan Provincial Education Department [19A180015]
- Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0459]
- High Level Research Fund for Qualified People of Henan University of Technology [31490068]
- National Key Research and Development Program of China [2017YFC1600600]
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GCP, a polysaccharide produced by endophytic fungus Chaetamiurn globosum CGMCC 6882, was found to be antibacterial against Staphylococcus aureus via disrupting cell permeability. However, the antibacterial mechanism of GCP has not been studied before. In present work, results showed that GCP could retard the growth of S. aureus by inducing the depolarization of cell membrane, decreasing the activity of Ca2+-Mg2+-ATPase on cell membrane, and increasing the accumulation of calcium ions in cytoplasm. Moreover, we found that GCP could also inhibit the synthesis of whole cell proteins of S. aureus. Overall, this study proved that the antibacterial mechanism of GCP could be diversified and more studies are needed in the investigation of the antibacterial mechanisms of various polysaccharides. (C) 2020 Elsevier B.V. All rights reserved.
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