Chemically crosslinked xylan-β-Cyclodextrin hydrogel for the in vitro delivery of curcumin and 5-Fluorouracil

Novel hydrogels were synthesized from xylan and 13-Cyclodextrin using Ethylene Glycol Diglycidyl Ether as a crosslinker in alkaline medium at different molar ratio. The physical characterization of hydrogels was carried out by the swelling study whereas the chemical characterization was performed in Fourier Transform Infrared Spectroscopy. The morphological analysis revealed the porous structure of hydrogel and the rheological study summarised the flow behavior and gelation characteristics of the hydrogels. Curcumin and 5-Fluorouracil (5 -FU) were used as the model drugs to be loaded in hydrogel and subsequent studies involving the in vitro release in phosphate buffer saline (PBS, pH = 7.4). The hydrogels showed drug loading of 98% of 5-FU and 26% of curcumin. Furthermore, the gels showed the highest cumulative release of 56% 5-FU and 37% curcumin after 24 h. The kinetics of drug release was then analyzed by various kinetic models. (C) 2020 Elsevier B.V. All rights reserved.