Glossary for randomized clinical trials

Randomized clinical trials are positioned at the highest level of primary clinical evidence, as they are designed to be unbiased with a reduced risk of systematic error. The Consolidated Standards of Reporting Trials (CONSORT) statement was first developed in 1996 to improve the reporting quality of randomized clinical trials with updates being published subsequently. Recently, the Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines were developed exclusively for the field of Endodontics to address the suboptimal quality of randomized clinical trials submitted to Endodontic journals, which result in many being rejected. A principal flaw in submissions is the fact that many authors are unclear on the keys terms that should be used when developing manuscripts for publication. Clearly, authors should be aware of the most common terms used when conducting and reporting randomized clinical trials. Hence, the aim of the current paper is to present a comprehensive glossary of the terminology used in randomized clinical trials in order to assist authors when designing, executing and writing-up randomized clinical trials.

Automated summary

Randomized clinical trials are considered the highest level of primary clinical evidence due to their unbiased design and reduced risk of systematic error. The CONSORT statement, developed in 1996, aims to improve the reporting quality of randomized clinical trials, with subsequent updates. The PRIRATE 2020 guidelines, specifically for Endodontics, address the issue of suboptimal quality trials submitted to Endodontic journals.