Journal
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
Volume 34, Issue 4, Pages 887-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2020.06.002
Keywords
Aminoglycosides; 16S rRNA methyltransferases; Gram-negative bacteria; Plazomicin
Categories
Funding
- Japan Society for the Promotion of Science
- National Institutes of Health [R01AI104895, R21AI135522]
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Aminoglycoside-resistant gram-negative pathogens producing 16S ribosomal RNA (rRNA) methyltransferase (MTase) have emerged and spread globally. 16S rRNA MTase-producing gram-negative pathogens tend to show a multidrugresistance profile against b-lactams and fluoroquinolones. 16S rRNA MTase producers resist the newly approved aminoglycoside, plazomicin. Treatment options are limited for infections caused by multidrug-resistant 16S rRNA MTase producers.
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